Defeating The School Yard Boss

Stand in the trash can. You can kill all the zombies at the beginning, then when he appears, just run back to the trash can and kill everything that comes at you. Watch the boss for his ground attacks and jump up to avoid them. If he starts to hit you, jump out, run around, then go back to the trash can. When you jump out you can always run to the Glyph and heal before returning.

Defeating The Man With The Knives In His Hands

To defeat him, you must destroy the chair at the top of the room. First, get the rocket launcher and flame thrower found during the level. When fighting him, run in circles so he cannot get you (Martyr recommended) while shooting the chair with the launcher. When you run out of rockets, use the flame thrower. Note: The chair will shoot out blasts of "energy" unexpectedly. Burn the chair from the sides. With the chair out of the way, run in circles while shooting him. If you run out of rockets and gas for the flame thrower restart the game, as the other guns do almost nothing to the chair.

Defeating The Last Boss

As any character, grab the machine gun at the lower left of the screen. Use any weapon to hurt the Boss. When he goes to recharge, run to the big window in the room and unload your Uzi, Shotgun, Chainsaw, or other weapon into it until it breaks open and the Boss dies. You can pretty much ignore him when he returns from getting charged, since you will be standing on a Health Glyph while destroying the window. Vampire and sunlight equals death. When you get to the last Boss, do not free the three locked up innocents unless you have low remaining lives. Freeing them will make the Boss have two more images of himself, creating three Bosses, but only one will be real.

Defeating The Teddy Bear Boss

Either wait until he dives before slice him with your knife/ax, or wait until he tries his puke attack and hit him from behind. This may take a while, but you should not lose a life when fighting this Boss. There is a Health Glyph in the lower left corner. Do not kill the blue flying enemies, as they just respawn as soon as they die. Play at least with two players, with one being Martyr. First, destroy all the benches for easier movement. Have Martyr get the bear's attention then run around in a circle. You are faster than the bear and he will chase you, but will not be able to hit. While he is chasing you, have your partner unload on him. When he gets down to low health, he might try to puke on you. Just get his attention again and repeat. If you run fast enough, you might be able to chase him, and hit him from behind. As any character, you need to master using the Analog-stick and C-stick simultaneously to run backwards and fire your weapon at the same time. Run in circles around the room, picking up shotguns and machine guns. Picked up shotguns seem to do the most damage. Continue running backwards and firing the weapons you have picked up. Disregard the blue ghosts. As long as you are running, they cannot hit you. Using this technique, you can defeat the Teddy Bear without losing any lives or having to use the glyphs, relatively quickly.

Defeat The Enemy With Knives In His Hands

Load up your rocket launcher before you go in the electric chair room. Run to the middle of the room, avoiding him. Run around in circles with the Launcher pointed at the chair. Keep shooting it while you run in circles. Make your circles just big enough to avoid him and do not accidentally shoot him at point blank range or you will lose a life. Change your direction when he changes his. The chair should explode after awhile. You can then just shoot him at your leisure or slice him up a bit before regenerating your health. You should be able to kill him without losing a life.

Freeze Your Enemies

If you are running or walking around and notice a Zombie or tree whip spawning (coming to life), get there fast enough and stand on top of the place that it is appearing from. The enemy will be frozen and unable to hurt you. Be careful, as many times you may get stuck with the enemy and be unable to fight. If this does happen, take out your melee weapon and hack away until you are free. Note: This does not work with small enemies (dogs, rats, alligators and skitters).

Killing Enemies Through Fences

Use the following trick to kill enemies without taking damage. When in a level with fences, such as at the Prisons, stand behind one with your unlimited long-range weapon and fire through. If done correctly, you should be able to kill anything you see through the fence. You can also walk through a fence. Once on the other side, wait until zombies or other enemy appears, then and run back through the door. Fire at them until they are dead.

Catacombs: Hidden Power-up

When you enter the room with the two sisters/innocents, defeat all the enemies but do not leave. Search the walls in that room and find the spot where the wall is cracked. Attack it with any weapon. It will eventually collapse. Inside are some special weapons (shotgun, etc.) and the permanent strength power-up.