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GameCube "S" Games
- Samurai Jack: The Shadow of Aku
- Scaler
- Scooby Doo: Mystery Mayhem
- Scooby Doo: Night of 100 Frights
- Scooby Doo: Unmasked
- The Scorpion King: Rise of the Akkadian
- SeaWorld: Shamu's Deep Sea Adventures
- Second Sight
- Sega Soccer Slam
- Serious Sam: Next Encounter
- Shadow the Hedgehog
- Shark Tale
- Shox
- Shrek 2
- Shrek Smash 'n' Crash Racing
- Shrek Superslam
- Shrek: Extra Large
- Shrek: Super Party
- The Simpsons: Hit and Run
- The Simpsons: Road Rage
- The Sims 2
- The Sims 2: Pets
- The Sims Bustin Out
- The Sims
- Skies of Arcadia Legends
- Smashing Drive
- Smuggler's Run: Warzones
- Sonic Adventure 2 Battle
- Sonic Adventure DX
- Sonic Gems Collection
- Sonic Heroes
- Sonic Mega Collection
- Sonic Riders
- Soul Calibur II
- Space Raiders
- Spartan: Total Warrior
- Spawn: Armageddon
- Speed Kings
- Sphinx and the Cursed Mummy
- Spider-Man 2
- Spider-Man: The Movie
- Spirits & Spells
- Splinter Cell
- SpongeBob SquarePants: Creature from the Krusty Krab
- SpongeBob SquarePants: Lights, Camera, Pants!
- SpongeBob SquarePants: Revenge of the Flying Dutchman
- SpongeBob SquarePants: The Movie
- SpongeBob: The Battle for Bikini Bottom
- Spy Hunter
- Spyro: A Hero's Tail
- Spyro: Enter the Dragonfly
- SSX 3: Out of Bounds
- SSX Tricky
- SSX: On Tour
- Star Fox Adventures: Dinosaur Planet
- Star Fox Assault
- Star Wars Jedi Knight II: Jedi Outcast
- Star Wars Rogue Leader: Rogue Squadron II
- Star Wars Rogue Squadron III: Rebel Strike
- Star Wars: Bounty Hunter
- Star Wars: The Clone Wars
- Starfox Adventures
- Starsky & Hutch
- Street Hoops
- Street Racing Syndicate
- Strike Force Bowling
- The Suffering
- The Sum of All Fears
- Summoner 2
- Super Bubble Pop
- Super Mario Strikers
- Super Mario Sunshine
- Super Monkey Ball
- Super Monkey Ball 2
- Super Monkey Ball Adventure
- Super Paper Mario
- Super Smash Bros. Melee
- Superman: Shadow of Apokolips
- Surf's Up
- Swingerz Golf
- SX Superstar
- System Info